Estimation of Blood Oxygen Saturation in the Circulation Circuit for Extracorporeal Membrane Oxygenation

IEEE Access

Kazuya Nakano¹  Takashi Ohnishi¹  Hideaki Haneishi¹  Yutaka Furukawa²  Shigeto Oda³  Taka-Aki Nakada³  Makoto Adachi⁴ 

[1] Center for Frontier Medical Engineering, Chiba University, Chiba, Japan;Chiba University Hospital, Chiba, Japan;Graduate School of Medicine, Emergency and Critical Care Medicine, Chiba University, Chiba, Japan;Graduate School of Science and Engineering, Chiba University, Chiba, Japan;

关键词: Biomedical monitoring;    spectroscopy;    circulators;   

DOI  :  10.1109/ACCESS.2019.2946905

来源: DOAJ

【 摘 要 】

Extracorporeal membrane oxygenation (ECMO) is a treatment that supports heart and lung functions with a circulation circuit external to the body. In ECMO, it is important to monitor blood oxygen saturation (SO₂) in the circulation tube. As a means of continuous SO₂ measuring, a special connector is inserted into the circuit. However, this method is unsuitable for emergency treatment. Therefore, it is necessary to measure blood SO₂ in the tube without the connector. However, this creates problems for SO₂ estimation, due to varying blood concentration and flow velocity, hemolysis, and wall thickness of the tube. Therefore, we developed a SO₂ estimation method that can calibrate the variation in blood concentration. The method is based on a conversion model between absorbance and SO₂ (CAS), which varies depending on the concentration. In this method, the CAS for the SO₂ estimation is estimated by CAS corresponding to two blood samples prepared in advance with different concentrations. The experiment for SO₂ estimation was conducted with a spectroscope, a halogen light source, and a cut tube. We confirmed that the average error of estimated SO₂ against the SO₂ values measured by a gas analysis was 3.8% within a blood volume concentration range from 50 to 90%. In future work, to improve the estimation accuracy, we will improve our method by investigating other factors that may affect the accuracy.

【 授权许可】

Unknown