The Association of Life’s Simple 7 with Aldosterone among African Americans in the Jackson Heart Study

Nutrients

Ehimare Akhabue¹  Yubo Tan²  David Kline²  Guy Brock²  Morgana Mongraw-Chaffin³  HermanA. Taylor⁴  ValeryS. Effoe⁴  Bjorn Kluwe⁵  Veena Kesireddy⁵  Mario Sims⁶  JamesB. Odei⁷  JoshuaJ. Joseph⁸  RitaR. Kalyani⁹  JustinB. Echouffo Tcheugui⁹ 

[1] Prevention, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA;Department of Biomedical Informatics and Center for Biostatistics, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA;;Department of Epidemiology &Department of Medicine, Morehouse School of Medicine, Atlanta, GA 30310, USA;Department of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA;Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA;Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, OH 43210, USA;Division of Cardiovascular Diseases and Hypertension, Rutgers University Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA;Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;

关键词: aldosterone;    ideal cardiovascular health;    Life’s Simple 7;    African Americans;    physical activity;    body mass index;    smoking;    blood pressure;    glucose;    cholesterol.;   

DOI  :  10.3390/nu11050955

来源: DOAJ

【 摘 要 】

Background: Among African Americans (AAs), attaining higher levels of American Heart Association (AHA) ideal cardiovascular health (Life’s Simple 7 [LS7]) is associated with lower risk of diabetes and cardiovascular disease (CVD). We previously showed that aldosterone is associated with higher risk of diabetes and CVD in AAs. Thus, we investigated the association of LS7 metrics with aldosterone in the Jackson Heart Study (JHS). Methods: Ideal metrics were defined by AHA 2020 goals for health behaviors (smoking, dietary intake, physical activity, and body mass index) and health factors (total cholesterol, blood pressure, and fasting glucose). The number of ideal LS7 metrics attained at baseline were summed into a continuous score (0−7) and categorical groups (Poor: 0−1, Intermediate: 2−3, and Ideal: ≥4 ideal LS7 metrics). Multivariable linear regression was used. Results: Among 4,095 JHS participants (mean age 55 ± 13 years, 65% female), median serum aldosterone was 4.90, 4.30, and 3.70 ng/dL in the poor (n = 1132), intermediate (n = 2288) and ideal (n = 675) categories respectively. Aldosterone was 15% [0.85 (0.80, 0.90)] and 33% [0.67 (0.61, 0.75)] lower in the intermediate and ideal LS7 categories compared to the poor LS7 category. Each additional LS7 metric attained on continuous LS7 score (0−7) was associated with an 11% [0.89 (0.86, 0.91)] lower aldosterone level with variation by sex with women having a 15% lower aldosterone vs. 5% in men. Conclusions: Higher attainment of ideal LS7 metrics was associated with lower serum aldosterone among AAs with a greater magnitude of association among women compared to men.

【 授权许可】

Unknown