Polyherbal EMSA ERITIN Promotes Erythroid Lineages and Lymphocyte Migration in Irradiated Mice

Open Life Sciences

Christina Yuyun Ika¹  Rifa’i Muhaimin¹  Ibrahim Mansur² 

[1] Department of Biology, Faculty of Mathematics and Natural Sciences, University of Brawijaya, Malang, Indonesia 65145;Department of Biomedical Sciences, Faculty of Medicine, University of Brawijaya, Malang, Indonesia 65145;

关键词: cd123;    erythropoiesis;    irradiation;    polyherbal;    sdf-1;    ter-119;   

DOI  :  10.1515/biol-2016-0003

来源: DOAJ

【 摘 要 】

Radiotherapy is commonly used to kill malignant cells, but it can significantly deplete hematopoietic and splenic erythroblasts. Radioprotective agents are therefore very important in clinical radiotherapy. We examined the effect of poly-herbal EMSA ERITIN on immunological responses when administered to sublethally irradiated mice with the aim of highlighting promotes erythroid lineages and lymphocytes migration in irradiated mice with the parameter are TER119+CD123+in bone marrow and SDF-1 in bone marrow and spleen organ. Normal BALB/c mice were sublethally irradiated with 600 rad. EMSA ERITIN was administered orally at different doses:(1.04, 3.125 and 9.375 mg/g body weight) for 15 days. On day 16 erythroid lineages (TER-119+CD123+) were observed in bone marrow and lymphocytes migration by the production of SDF-1 in spleen and bone marrow. Lymphocytes migration was indicated by the production of SDF-1 in spleen and bone marrow using flow cytometry analysis. EMSA ERITIN increased the generation of erythroid lineage cells marked by TER119+CD123+ and promoted lymphocyte migration by increasing SDF-1 production in bone marrow and spleen. EMSA ERITIN appears to be a powerful medicinal herb with potential as a food supplement to normalize homeostasis and erythropoiesis after radiation.

【 授权许可】

Unknown