Vascular Leak and Hypercytokinemia Associated with Severe Fever with Thrombocytopenia Syndrome Virus Infection in Mice

Pathogens

BradyT. Hickerson¹  JonnaB. Westover¹  Ashley Dagley¹  JacquelineP. Kurz¹  BrianB. Gowen¹  ArnaudJ. Van Wettere¹  BrettL. Hurst¹  Takashi Komeno²  Yousuke Furuta²  Petra Wülfroth³  Thomas Steiner³ 

[1] Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322, USA;FUJIFILM Toyama Chemical Co., Ltd., Toyama 930-8508, Japan;MChE-Trading Handels-GmbH, Vienna 1060, Austria;

关键词: severe fever with thrombocytopenia syndrome;    Huaiyangshan banyangvirus;    viral hemorrhagic fever;    vascular leak;    cytokine storm;   

DOI  :  10.3390/pathogens8040158

来源: DOAJ

【 摘 要 】

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral hemorrhagic fever (VHF) endemic to China, South Korea, Japan, and Vietnam. Here we characterize the pathogenesis and natural history of disease in IFNAR^-/- mice challenged with the HB29 strain of SFTS virus (SFTSV) and demonstrate hallmark features of VHF such as vascular leak and high concentrations of proinflammatory cytokines in blood and tissues. Treatment with FX06, a natural plasmin digest product of fibrin in clinical development as a treatment for vascular leak, reduced vascular permeability associated with SFTSV infection but did not significantly improve survival outcome. Further studies are needed to assess the role of vascular compromise in the SFTS disease process modeled in IFNAR^-/- mice.

【 授权许可】

Unknown