A collagen(Col)/nano-hydroxyapatite (nHA) biological composite bone scaffold with double multi-level interface reinforcement

Arabian Journal of Chemistry

Hongyun Xing¹  Tierong Bian² 

[1]Hematology Department, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China

[2]Medical Experimental Center, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China

关键词: Bionic bone structure;    Biomineralization;    Mineralization nucleation mechanism;    nHA array;    The double multiscales strengthening mechanism;   

DOI  :  

来源: DOAJ

【 摘 要 】

Introduction: Bone scaffold is expected to possess excellent mechanical and biological properties similar to natural bone tissues. In this study, we aimed to prepare a biomineralized Col and hydroxyapatite composite scaffold consisting of biomimetic bone components and multi-level bionic bone structure to strengthen its mechanical properties. Methods: We prepared a Col/nano-hydroxyapatite biological composite scaffold with multi-level structure (from nanofibers to micron bionic bone motif to bionc bone scaffold) of biomimetic bone tissue, and biomineralized the scaffold in simulated body fluid (SBF) preheated to 37 °C. X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and Scanning electron microscope, were used to characterize the biomineralized products. Results: Morphological study confirmed in situ deposition of nHA in the multi-scale hierarchical structure of the biomineralized scaffold. We explored the biomineralization nucleation mechanism of the scaffolds at the atomic level based on the first principles and the mechanisms for growth of mineralized nHA crystal array in its multi-scale structure, and how the double multiscales structure strengthened the mechanical properties of the material. Conclusions: This synthetic bone scaffold, with bionic bone composition and double multi-level interface reinforcement, provides a new strategy for synthesizing bioactive bone scaffolds with enhanced biomechanical properties.

【 授权许可】

Unknown