Anticancer Activity and Apoptosis Induction of Gold(III) Complexes Containing 2,2′-Bipyridine-3,3′-dicarboxylic Acid and Dithiocarbamates

Molecules

Saeed Ahmad¹  Muhammad Monim-ul-Mehboob²  Anvarhusein A. Isab³  Adam A. A. Sulaiman³  Homood M. As Sobeai⁴  Moureq Alotaibi⁴  Khalid Alhazzani⁴  Wajhul Qamar⁴  Ali Alhoshani⁴ 

[1] Department of Chemistry, College of Sciences and Humanities, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia;Department of Chemistry, Government College of Science, Wahdat Road, Lahore, Pakistan;Department of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia;Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia;

关键词: gold(III);    2,2′-bipyridine-3,3′-dicarboxylic acid;    anti-cancer activity;    dithiocarbamates;    apoptosis;   

DOI  :  10.3390/molecules26133973

来源: DOAJ

【 摘 要 】

Three novel gold(III) complexes (1–3) of general composition [Au(Bipydc)(S₂CNR₂)]Cl₂ (Bipydc = 2,2′-bipyridine-3,3′-dicarboxylic acid and R = methyl for dimethyldithiocarbamate (DMDTC), ethyl for diethyldithiocarbamate (DEDTC), and benzyl for dibenzyldithiocarbamate (DBDTC)) have been synthesized and characterized by elemental analysis, FTIR and NMR spectroscopic techniques. The spectral results confirmed the presence of both the Bipydc and dithiocarbamate ligands in the complexes. The in vitro cytotoxic studies demonstrated that compounds 1–3 were highly cytotoxic to A549, HeLa, MDA-231, and MCF-7 cancer cells with activities much higher (about 25-fold) than cisplatin. In order to know the possible mode of cell death complex 2, [Au(Bipydc)(DEDTC)]Cl₂ was further tested for induction of apoptosis towards the MCF-7 cells. The results indicated that complex 2 induces cell death through apoptosis.

【 授权许可】

Unknown