Dynamic changes in T-cell subsets and C-reactive protein after radiation therapy in lung cancer patients and correlation with symptomatic radiation pneumonitis treated with steroid therapy

Cancer Management and Research

关键词: T-cell subsets;    radiation pneumonitis;    steroid therapy;    radiotherapy;    C-reactive protein;   

DOI  :  

来源: DOAJ

【 摘 要 】

Lu Bai,1 Bao-Sen Zhou,2,3 Yu-Xia Zhao41Department of Radiation Oncology, First Affiliated Hospital of China Medical University, Shenyang 110001, People’s Republic of China; 2Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110122, People’s Republic of China; 3Liaoning Provincial Department of Education, Key Laboratory of Cancer Etiology and Prevention, First Affiliated Hospital of China Medical University, Shenyang 110001, People’s Republic of China; 4Department of Radiation Oncology, Fourth Affiliated Hospital of China Medical University, Shenyang 110032, People’s Republic of ChinaCorrespondence: Yu-Xia ZhaoDepartment of Radiation Oncology, Fourth Affiliated Hospital of China Medical University, 4 Eastern Chongshan Road, Huanggu District, Shenyang Liaoning 110032, People’s Republic of ChinaTel [phone]Email [e-mail]: To investigate relationships among serum T-cell subsets, CRP, levels and radiation pneumonitis (RP) in lung cancer patients receiving radiotherapy.Methods: A case–control study with frequency matching was carried out. The case group comprised 36 lung cancer patients who had developed grade ≥2 RP after thoracic radiotherapy. The control group was 36 patients with lung cancer without RP. Patients in the case group received steroid therapy for 1 month after diagnosis of RP and were followed up for 3 months. T-cell subsets, CRP, and pulmonary function were detected at three time points (onset of RP and 1 and 3 months after diagnosis). Data for the control group were collected 3 months after radiotherapy. Treatment effectiveness was evaluated at 1 and 3 months after diagnosis of RP.Results: Of the 36 patients in the case group, three with grade5 RP died from respiratory failure. The other 33 cases had all improved with steroid therapy at 3 months after RP diagnosis. In these 33, CD3+,T-cell quantity, CD4+,T-cell quantity, and of CD4+,:CD8+, ratio in T-cell subsets decreased significantly and CRP increased (P<0.05) at the onset of RP compared with the control group. After steroid therapy, CD4+,T-cell quantity increased significantly compared to before treatment. The same change was seen in CD4+,:CD8+, ratio, whereas CRP levels decreased obviously, with treatment effectiveness improved. In addition, with the damage level of RP increased, CD4+, T -cell quantity decreased obviously and CRP levels increased accordingly at the onset of RP (P<0.05).Conclusion: T-cell subsets and CRP may become effective immunological biomarkers for predicting damage from RP and evaluating treatment effectivesness of steroid therapy.Keywords: T-cell subsets, radiation pneumonitis, steroid therapy, radiotherapy, C-reactive protein

【 授权许可】

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