In Silico Study of Plant Polyphenols' Interactions with VP24–Ebola Virus Matrix Protein

Acta Chimica Slovenica

Sebastian Pleško¹  Miha Lukšič¹  Helena Volk¹  Črtomir Podlipnik¹ 

[1] 1Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI-1000 Ljubljana, Slovenia;

关键词: Ebola virus;    VP24;    KPNA5;    STAT1;    plant polyphenols;    molecular docking;   

DOI  :  10.17344/acsi.2015.1505

来源: DOAJ

【 摘 要 】

The Zaire Ebola viral protein VP24 selectively inhibits nuclear import of STAT1 and as such blocks interferon-induced antiviral responses vital for cell's emergency. Inhibition of VP24 with small molecule inhibitor may neutralize the threatening action of Ebola virus. We performed molecular docking of compounds from a selected small library of plant polyphenols on to VP24. Our research shows that 1,2,3,6–tetragalloyl glucose, epigallocatechin gallate, chlorogenic acic, oleuropein and miquelianin represent promising leads for further studies.

【 授权许可】

Unknown