Compound glycyrrhizin injection for improving liver function in children with acute icteric hepatitis: A systematic review and meta-analysis

Integrative Medicine Research

Jian-Ping Liu¹  Li-Jiao Yan²  Wen-Bin Hou²  Chang-Hao Liang²  Mei Han²  Shi-Bing Liang²  Ruo-Xiang Zheng²  Hui-Juan Cao²  Nicola Robinson³  Hao-Nan Wang⁴ 

[1] Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China;Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China;Institute of Health and Social Care, London South Bank University, London, UK;School of Basic Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China;

关键词: Glycyrrhizin;    Acute icteric hepatitis;    Randomized trials;    Liver function;    Systematic review;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Compound glycyrrhizin injection (CGI) is a preparation with glycyrrhizin as the main active ingredient extracted from licorice. As clinical trials suggest that CGI is effective in improving liver function for acute icteric hepatitis in children (AIHC), this systematic review aimed to evaluate and verify its therapeutic effects and safety. Methods: Six electronic databases were searched from their inception to 15 May 2021. Randomized controlled trials (RCTs) assessing therapeutic effects and safety of CGI for AIHC were included. The risk of bias for each trial was assessed using the Cochrane Risk of Bias Tool 2.0. Primary outcomes were indexes related to liver function, including total bilirubin (TBiL), alanine aminotransferase (ALT) and aspartate transaminase (AST). RevMan 5.4 software was used for data analyses. The certainty of the evidence was assessed using the online GRADEpro tool. Results: Six RCTs involving 608 children were included. The overall bias was assessed as having “high risk of bias” in all trials. All trials compared the combination of CGI and conventional western medicine (CWM) with CWM alone. Regarding the effects of CGI for AIHC, results showed that CGI plus CWM was superior to CWM alone in reducing the levels of TBiL (mean difference (MD) = -8.19 mmol/L, 95% CI -9.86 to -6.53), ALT (MD = -24.09 U/L, 95% CI -30.83 to -17.34) and AST (MD = -18.67 U/L, 95% CI -21.88 to -15.45). No trial reported adverse events. The certainty of the evidence for outcomes were all evaluated as low or very low. Conclusion: CGI may have adjuvant therapeutic effects on improving the liver function of children with AIHC. There is no evidence to determine the safety of CGI for AIHC. As current evidence is weak, further well-designed RCTs are required for verification of the therapeutic effects of CGI.

【 授权许可】

Unknown