期刊论文详细信息
Frontiers in Endocrinology
Bone Density and Structure in Overweight Men With and Without Diabetes
Simon Lykkeboe1  Aase Handberg2  Marie Juul Ornstrup3  Thomas Nordstrøm Kjær3  Torben Harsløf3  Bente Lomholt Langdahl3  Peter Vestergaard4  Steen Bønløkke Pedersen5  Søren Gregersen5  Jakob Starup-Linde6 
[1] Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark;Department of Clinical Medicine, The Faculty of Medicine, Aalborg University, Aalborg, Denmark;Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark;Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark;Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark;Steno Diabetes Center North Jutland, Aalborg University Hospital, Aalborg, Denmark;
关键词: diabetes;    metabolic syndrome;    bone turnover (markers);    bone mineral density;    HRpQCT;   
DOI  :  10.3389/fendo.2022.837084
来源: DOAJ
【 摘 要 】

ObjectiveMetabolic syndrome (MetS), type 1 diabetes (T1D), and type 2 diabetes, are associated with an increased risk of fractures; however, the impact of obesity on bone deficits in diabetes is unknown. We aimed to compare markers of bone structure, bone density, and bone turnover in non-diabetic overweight men with MetS and overweight men with T1D or T2D.Methods and Research DesignIn this cross-sectional study we included participants from two previously described study cohorts consisting of participants with diabetes and participants with MetS. Participants underwent dual-energy X-ray absorptiometry measuring areal bone mineral density (aBMD) at the hip and lumbar spine, High Resolution peripheral Quantitative (HRpQCT) scan of the tibia and radius and measurement of circulating bone turnover markers. We compared groups with unpaired t test and performed multiple linear regression with adjustment for age, body mass index, and smoking.ResultsWe included 33 participants with T1D, 25 participants with T2D, and 34 participants with MetS. Bone turnover markers levels were comparable between T1D and MetS. aBMD at the hip was lower in T1D compared to MetS, also after adjustment. P1NP and Osteocalcin levels were lower among individuals with T2D compared to MetS, whereas aBMD were similar between the groups after multiple adjustments. We observed no difference in volumetric BMD at the tibia or radius between MetS and T1D and T2D, respectively. Participants with T2D had a higher trabecular number and lower trabecular separation compared to individuals with MetS at the tibia, which remained signficant after multiple adjustments.ConclusionIn conclusion, we observed no clinically important differences in bone density or structure between men with T2D, T1D, or MetS. However, men with T2D displayed lower bone turnover compared to MetS highlighting that T2D per se and not obesity, is associated with low bone turnover.

【 授权许可】

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