Microbiota Gut-Brain Axis and Neurodegenerative Disease

Romanian Neurosurgery

关键词: gut dysbiosis;    central nervous system;    gastrointestinal tract;    enteric nervous system;    neuroimmune system;    neuroendocrine system;   

DOI  :  

来源: DOAJ

【 摘 要 】

This review highlights the microbiota gut-brain axis and neurodegenerative diseases excluding studies on animal models. Gut microbiota is capable of modulating some brain activities via the microbiota gut-brain axis. A bidirectional communication exists between the gastrointestinal (GI) tract and the central nervous system (CNS) in the microbiota gut-brain axis. Gut dysbiosis has been linked to neurodegenerative diseases as a result of the imbalance in the composition of its microbiota, which has a damaging effect on the host’s health. The association between the role and mechanism of CNS disease and gut microbial is yet to be fully explored. Although some studies have shown a positive relationship between a rich diverse microbial community and the brain of the host, and a negative relationship between microbial dysbiosis, intestinal infection and human brain health, our knowledge, however, is limited due to the inability to identify the major players in this heterogeneous microbial community.

【 授权许可】

Unknown