Effect of Adjuvant and Palliative Chemotherapy in Large Cell Neuroendocrine Carcinoma of the Lung: A Systematic Review and Meta-Analysis

Cancers

Nobuyuki Horita¹  Masashi Ishihara²  Nobuhiko Seki²  Ryusuke Ochiai²  Yasuko Ichikawa²  Kiyotaka Watanabe²  Hao Chen²  Takeshi Honda²  Hiroki Kazahari²  Shigeru Tanzawa² 

[1]Department of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama 236-0027, Japan

[2]Division of Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo 173-8606, Japan

关键词: large cell neuroendocrine carcinoma of the lung;    chemotherapy;    regimen;    small cell lung cancer;    non-small cell lung cancer;   

DOI  :  10.3390/cancers13235948

来源: DOAJ

【 摘 要 】

Background: Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a rare subset of lung carcinoma with poor overall survival. Methods: A systematic review following a meta-analysis of studies was performed to identify the effect of different selections of chemotherapy in LCNEC. Articles providing overall survival data for adjuvant chemotherapy or palliative chemotherapy for LCNEC were eligible. The odds ratio (OR) of mortality at one or two years after chemotherapy was evaluated. Results: A total of 16 reports were finally included in the quantitative synthesis, involving a total of 5916 LCNEC patients. Adjuvant chemotherapy was administered to 1303 patients, and palliative chemotherapy was administered to 313 patients using either a small cell lung cancer (SCLC) or a non-small cell lung cancer (NSCLC) regimen. The OR for adjuvant chemotherapy was 0.73 (95% confidence interval (CI): 0.59 to 0.89, p = 0.002). The SCLC regimen showed an OR of 0.52 (95% CI: 0.11 to 2.38, p = 0.40) after one year, and 0.32 (95% CI: 0.11 to 0.89, p = 0.03) after two years, compared with the NSCLC regimen. Conclusions: Adjuvant chemotherapy for pulmonary large cell neuroendocrine carcinoma improved the outcome after surgery. The SCLC regimen showed better survival than the NSCLC regimen as palliative chemotherapy.

【 授权许可】

Unknown