Cancer-Associated Fibroblasts Influence the Biological Properties of Malignant Tumours via Paracrine Secretion and Exosome Production

International Journal of Molecular Sciences

Yi Zhen Ng¹  Jan Brábek²  Lukáš Lacina³  Karel Smetana³  Michal Kolář⁴  Martin Vokurka⁵ 

[1] A*STAR Skin Research Labs (A*SRL)—Biopolis, Skin Research Institute of Singapore, 8A Biomedical Grove 06-06 Immunos Singapore, Singapore 138665, Singapore;Department of Cell Biology, Faculty of Science, Charles University, 120 00 Prague 2, Czech Republic;Institute of Anatomy, First Faculty of Medicine, Charles University, 120 00 Prague 2, Czech Republic;Institute of Molecular Genetics, Czech Academy of Sciences, 142 20 Prague 4, Czech Republic;Institute of Pathological Physiology, First Faculty of Medicine, Charles University, 120 00 Prague 2, Czech Republic;

关键词: cancer microenvironment;    cancer ecosystem;    cancer-associated fibroblast;    IL-6;    exosome;   

DOI  :  10.3390/ijms23020964

来源: DOAJ

【 摘 要 】

Cancer-associated fibroblasts (CAFs) are an essential component of the tumour microenvironment. They represent a heterogeneous group of cells that are under the control of cancer cells and can reversely influence the cancer cell population. They affect the cancer cell differentiation status, and the migration and formation of metastases. This is achieved through the production of the extracellular matrix and numerous bioactive factors. IL-6 seems to play the central role in the communication of noncancerous and cancer cells in the tumour. This review outlines the role of exosomes in cancer cells and cancer-associated fibroblasts. Available data on the exosomal cargo, which can significantly intensify interactions in the tumour, are summarised. The role of exosomes as mediators of the dialogue between cancer cells and cancer-associated fibroblasts is discussed together with their therapeutic relevance. The functional unity of the paracrine- and exosome-mediated communication of cancer cells with the tumour microenvironment represented by CAFs is worthy of attention.

【 授权许可】

Unknown