Sacraoxides A–G, Bioactive Cembranoids from Gum Resin of Boswellia sacra

Frontiers in Chemistry

Kazuo Koike¹  Wei Li¹  Koji Higai¹  Kouharu Otsuki¹  Bingyang Zhang²  Feng Qiu²  Wenyue Ji²  Di Liu²  Feng Zhao³ 

[1] Faculty of Pharmaceutical Sciences, Toho University, Tokyo, Japan;School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China;School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China;

关键词: Boswellia sacra;    olibanum;    phytochemistry;    cembranoids;    structure elucidation;    anti-inflammatory;   

DOI  :  10.3389/fchem.2021.649287

来源: DOAJ

【 摘 要 】

Seven undescribed cembranoids, sacraoxides A–G (1, 3–8) were isolated from the gum resin of Boswellia sacra. Their structures were elucidated by extensive physicochemical and spectroscopic analysis, as well as ECD calculation, modified Mosher’s method and X-ray diffraction crystallography. Compounds 6 and 7 exhibited inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide in RAW264.7 cells with IC50 values of 24.9 ± 1.7 and 36.4 ± 2.9 μM.

【 授权许可】

Unknown