The epidemiological profile of chronic hepatitis C with advanced hepatic fibrosis regarding virus genotype in Taiwan: A nationwide study

Journal of the Formosan Medical Association

Wen-Wen Yang¹  Ding-Shinn Chen²  Po-Chang Lee³  Sheng-Nan Lu⁴  Rong-Nan Chien⁵  Shih-Chung Chen⁵  Grace Hui-Min Wu⁵  Chia-Ling Liu⁵  Raoh-Fang Pwu⁵ 

[1] Department of Physical Therapy and Assistive Technology, National Yang-Ming University, Taipei, Taiwan;Division of Hepatogastroenterology, Department of Internal Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan;School of Health Care Administration, Taipei Medical University, Taipei, Taiwan;National Health Insurance Administration, Ministry of Health and Welfare, Taipei, Taiwan;Taiwan National Hepatitis C Program Office, Ministry of Health and Welfare, Taipei, Taiwan;

关键词: Antiviral agents;    Epidemiology;    Hepatitis C;    Liver cirrhosis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background/Purpose: This study aims at investigating the epidemiological profile of chronic hepatitis C (CHC) regarding hepatitis C virus (HCV) genotype in Taiwan. Methods: A total of 29,087 CHC patients with advanced fibrosis who received direct-acting antivirals (DAAs) therapy under Taiwan's National Health Insurance (NHI) during 2017–2018 were recruited. The HCV genotype distribution and its association with patients' demographic factors including age, gender, and geographical areas were examined. Results: The most common genotypes were 1b (59.5%) and 2 (30.1%) with characteristics of older age (mean ± standard deviation (SD): 66.5 ± 10.7 years and 67.3 ± 10.9 years) and female gender predominant (57.1% and 59.4%), which were associated with iatrogenic infection decades ago. Most of patients with genotype 1a (5.9%) and 6 (3.7%) infection were relatively younger (59.2 ± 12.0 years and 60.0 ± 13.8 years) and male gender predominant (59.1% and 61.1%), except Liujia and Liuying districts in southern Taiwan. The youngest group (53.2 ± 11.8 years) and most male gender predominant (74.3%) was genotype 3 (0.37%). These genotypes with characteristics of being younger and male gender predominant were highly related to injection drug use in recent years. The number of genotype 4 patients were extremely rare (n = 25) and efficacy of genotype-4-specific-DAA was significantly poorer than non-genotype-4-specific DAA (P value = 0.0411). Conclusion: The significant differences in demographic characteristics among CHC patients with different HCV genotypes found in this study suggest HCV genotype was highly associated with transmission pattern and may be used as a reference for HCV control.

【 授权许可】

Unknown