Biomarkers in Stress Related Diseases/Disorders: Diagnostic, Prognostic, and Therapeutic Values

Frontiers in Molecular Biosciences

Hafiz M. N. Iqbal¹  Wanpen Chaicumpa²  Sunil Kumar Joshi³  Kumaragurubaran Karthik⁴  Rekha Khandia⁵  Ashok Munjal⁵  Ruchi Tiwari⁶  Sandip Chakraborty⁷  Kuldeep Dhama⁸  Karam Pal Singh⁸  Shyma K. Latheef⁸  Hari Abdul Samad⁹  Mohd. Iqbal Yatoo^1,10  Maryam Dadar^1,11  Prakash Bhatt^1,12 

[1] 0Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey, Mexico;1Department of Parasitology, Faculty of Medicine, Center of Research Excellence on Therapeutic Proteins and Antibody Engineering, Siriraj Hospital, Mahidol University, Bangkok, Thailand;;2Division of Hematology, Oncology and Bone Marrow Transplantation, Department of Microbiology &Central University Laboratory, Tamil Nadu Veterinary and Animal Sciences University, Chennai, India;Department of Genetics, Barkatullah University, Bhopal, India;Department of Veterinary Microbiology and Immunology, College of Veterinary Sciences, UP Pandit Deen Dayal Upadhayay Pashu Chikitsa Vigyan Vishwavidyalay Evum Go-Anusandhan Sansthan, Mathura, India;Department of Veterinary Microbiology, College of Veterinary Sciences and Animal Husbandry, Agartala, India;Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, India;Division of Physiology and Climatology, ICAR-Indian Veterinary Research Institute, Bareilly, India;Division of Veterinary Clinical Complex, Sher-E-Kashmir University of Agricultural Sciences and Technology of Kashmir, Srinagar, India;Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization, Karaj, Iran;Teaching Veterinary Clinical Complex, College of Veterinary and Animal Sciences, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, India;

关键词: biomarkers;    stress;    diagnosis;    prognosis;    therapeutic values;    acute phase proteins;   

DOI  :  10.3389/fmolb.2019.00091

来源: DOAJ

【 摘 要 】

Various internal and external factors negatively affect the homeostatic equilibrium of organisms at the molecular to the whole-body level, inducing the so-called state of stress. Stress affects an organism's welfare status and induces energy-consuming mechanisms to combat the subsequent ill effects; thus, the individual may be immunocompromised, making them vulnerable to pathogens. The information presented here has been extensively reviewed, compiled, and analyzed from authenticated published resources available on Medline, PubMed, PubMed Central, Science Direct, and other scientific databases. Stress levels can be monitored by the quantitative and qualitative measurement of biomarkers. Potential markers of stress include thermal stress markers, such as heat shock proteins (HSPs), innate immune markers, such as Acute Phase Proteins (APPs), oxidative stress markers, and chemical secretions in the saliva and urine. In addition, stress biomarkers also play critical roles in the prognosis of stress-related diseases and disorders, and therapy guidance. Moreover, different components have been identified as potent mediators of cardiovascular, central nervous system, hepatic, and nephrological disorders, which can also be employed to evaluate these conditions precisely, but with stringent validation and specificity. Considerable scientific advances have been made in the detection, quantitation, and application of these biomarkers. The present review describes the current progress of identifying biomarkers, their prognostic, and therapeutic values.

【 授权许可】

Unknown