Hyaluronic Acid-Functionalized Gadolinium Oxide Nanoparticles for Magnetic Resonance Imaging-Guided Radiotherapy of Tumors

Nanoscale Research Letters

Lin Wu¹  Chaoyang Wu¹  Lirong Zhang²  Tian Zhao²  Rong Cai³  Pengfei Li³  Miaomiao Zhang³  Lixia Xu³  Tao Li³  Jie Jin³  Fengyi Du³ 

[1] Department of Oncology, The Affiliated People’s Hospital, Jiangsu University;Department of Radiology, Affiliated Hospital of Jiangsu University;School of medicine, Jiangsu University;

关键词: Hyaluronic acid;    Gadolinium;    Radiosensitization;    MR imaging;   

DOI  :  10.1186/s11671-020-03318-9

来源: DOAJ

【 摘 要 】

Abstract Inaccuracy localization and intrinsic radioresistance of solid tumors seriously hindered the clinical implementation of radiotherapy. In this study, we fabricated hyaluronic acid-functionalized gadolinium oxide nanoparticles (HA-Gd2O3 NPs) via one-pot hydrothermal process for effective magnetic resonance (MR) imaging and radiosensitization of tumors. By virtue of HA functionalization, the as-prepared HA-Gd2O3 NPs with a diameter of 105 nm showed favorable dispersibility in water, low cytotoxicity, and excellent biocompatibility and readily entered into the cytoplasm of cancer cells by HA receptor-mediated endocytosis. Importantly, HA-Gd2O3 NPs exhibited high longitudinal relaxivity (r 1) 6.0 mM−1S−1 as MRI contrast agents and radiosensitization enhancement in a dose-dependent manner. These finds demonstrated that as-synthesized HA-Gd2O3 NPs as bifunctional theranostic agents have great potential in tumors diagnosis and radiotherapy.

【 授权许可】

Unknown