Preoperative Immunonutrition vs. Standard Dietary Advice in Normo-Nourished Patients Undergoing Fast-Track Laparoscopic Colorectal Surgery

Journal of Clinical Medicine

Marzia Franceschilli¹  Leandro Siragusa¹  AndreaM. Guida¹  Bruno Sensi¹  GiuseppeS. Sica¹  Andrea Divizia¹  Vittoria Bellato¹  Nicola Di Daniele²  Manfredi Tesauro² 

[1] Department of Surgical Science, University Tor Vergata, 00133 Rome, Italy;Department of Systems Medicine, University Tor Vergata, 00133 Rome, Italy;

关键词: immunonutrition;    ERAS;    laparoscopy;    colorectal surgery;   

DOI  :  10.3390/jcm10030413

来源: DOAJ

【 摘 要 】

Immunonutrition (IN) appears to reduce infective complications and in-hospital length of stay (LOS) after major gastrointestinal surgery, but its use in normo-nourished patients is still controversial. The primary aim of this comparative observational study was to evaluate if pre-operative IN reduces in-hospital stay in patients undergoing laparoscopic colorectal resection for cancer under an enhanced recovery after surgery (ERAS) program. The influence of IN on time to first bowel movements, time to full oral diet tolerance, number and type of complications, reasons of prolonged LOS and readmission rate was evaluated as secondary outcome. Patients undergoing ERAS laparoscopic colorectal resection between December 2016 and December 2019 were reviewed. Patients who have received preoperative IN (group A) were compared to those receiving standard dietary advice (group B). Mean in-hospital LOS was significantly shorter in patients receiving preoperative IN than standard dietary advice (4.85 ± 2.25 days vs. 6.06 ± 3.95 days; p < 0.0492). No differences in secondary outcomes were observed. Preoperative IN associated with ERAS protocol in normo-nourished patients undergoing laparoscopic colorectal cancer resection seems to reduce LOS.

【 授权许可】

Unknown