Tuneable access to indole, indolone, and cinnoline derivatives from a common 1,4-diketone Michael acceptor

Beilstein Journal of Organic Chemistry

Dalel El-Marrouki¹  Philippe C. Gros¹  Sabrina Touchet¹  Mohamed Lotfi Efrit²  Abderrahmen Abdelli²  Hédi M’Rabet² 

[1] Université de Lorraine, CNRS, L2CM, F-5400 Nancy, France;Université de Tunis El Manar, SOHES-LR17ES01, Tunis, Tunisia;

关键词: cinnoline;    1,4-diketone;    indole;    indolone;    n-heterocycle;   

DOI  :  10.3762/bjoc.16.144

来源: DOAJ

【 摘 要 】

A convergent strategy is reported for the construction of nitrogen-containing heterocycles from common substrates: 1,4-diketones and primary amines. Indeed, by just varying the substrates, the substituents, or the heating mode, it is possible to selectively synthesize indole, indolone (1,5,6,7-tetrahydroindol-4-one), or cinnoline (5,6,7,8-tetrahydrocinnoline) derivatives in moderate to excellent yields.

【 授权许可】

Unknown