Pancreatic Stellate Cells: A Rising Translational Physiology Star as a Potential Stem Cell Type for Beta Cell Neogenesis

Frontiers in Physiology

Yunting Zhou¹  Xiaohang Wang¹  Wei Li¹  Min Cai¹  Zilin Sun¹  Junming Zhou²  Feng Gao³  Bo Sun⁴ 

[1] Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, China;Department of Outpatient, Army Engineering University, Jingling Hospital, Nanjing University, Nanjing, China;Graduate Innovation Platform of Southeast University, Nanjing, China;State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China;

关键词: pancreatic stellate cell;    quiescent;    activation;    stem/progenitor cell;    physiological functions;    β-cells neogenesis;   

DOI  :  10.3389/fphys.2019.00218

来源: DOAJ

【 摘 要 】

The progressive decline and eventual loss of islet β-cell function underlies the pathophysiological mechanism of the development of both type 1 and type 2 diabetes mellitus. The recovery of functional β-cells is an important strategy for the prevention and treatment of diabetes. Based on similarities in developmental biology and anatomy, in vivo induction of differentiation of other types of pancreatic cells into β-cells is a promising avenue for future diabetes treatment. Pancreatic stellate cells (PSCs), which have attracted intense research interest due to their effects on tissue fibrosis over the last decade, express multiple stem cell markers and can differentiate into various cell types. In particular, PSCs can successfully differentiate into insulin- secreting cells in vitro and can contribute to tissue regeneration. In this article, we will brings together the main concepts of the translational physiology potential of PSCs that have emerged from work in the field and discuss possible ways to develop the future renewable source for clinical treatment of pancreatic diseases.

【 授权许可】

Unknown