Iodine and thyroid status during pregnancy and risk of stillbirth: A population‐based nested case–control study

Maternal and Child Nutrition

Heljä‐Marja Surcel¹  Un‐Jung Kim²  Kurunthachalam Kannan³  Alexandra C. Purdue‐Smithe⁴  Elijah Reische⁴  James L. Mills⁴  Mika Gissler⁵  Tuija Männistö⁶  Eila Suvanto⁷ 

[1] Biobank Borealis of Northern Finland Oulu University Hospital Oulu Finland;Department of Earth and Environmental Sciences University of Texas at Arlington Arlington Texas USA;Department of Pediatrics and Department of Environmental Medicine New York University School of Medicine New York New York USA;Division of Intramural Population Health Research, National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development Bethesda Maryland USA;Information Services Department Finnish Institute of Health and Welfare Helsinki Finland;Northern Finland Laboratory Center NordLab Oulu University Hospital Oulu Finland;Oulu University Hospital, Department of Children and Women and Oulu University Medical Faculty PEDEGO Research Unit Medical Research Center Oulu Finland;

关键词: iodine;    pregnancy;    pregnancy loss;    stillbirth;    thyroglobulin;    thyroid hormones;   

DOI  :  10.1111/mcn.13252

来源: DOAJ

【 摘 要 】

Abstract Prior research suggests that severe iodine deficiency in pregnancy may be associated with stillbirth. However, the relationship between mild to moderate iodine insufficiency, which is prevalent even in developed countries, and risk of stillbirth is unclear. We thus examined associations of iodine status and risk of stillbirth in a prospective population‐based nested case–control study in Finland, a mild to moderately iodine insufficient population. Stillbirth cases (n = 199) and unaffected controls (n = 249) were randomly selected from among all singleton births in Finland from 2012 to 2013. Serum samples were collected between 10 and 14 weeks gestation and analysed for iodide, thyroglobulin (Tg) and thyroid‐stimulating hormone (TSH). Odds ratios (ORs) and 95% confidence intervals (CIs) for stillbirth were estimated using logistic regression. After adjusting for maternal age, prepregnancy body mass index, socio‐economic status and other factors, neither high nor low serum iodide was associated with risk of stillbirth (Q1 vs. Q2–Q3 OR = 0.92, 95% CI = 0.78–1.09; Q4 vs. Q2–Q3 OR = 0.78; 95% CI = 0.45–1.33). Tg and TSH were also not associated with risk of stillbirth in adjusted models. Maternal iodine status was not associated with stillbirth risk in this mildly to moderately iodine‐deficient population. Tg and TSH, which reflect functional iodine status, were also not associated with stillbirth risk. The lack of associations observed between serum iodide, TSH and Tg and risk of stillbirth is reassuring, given that iodine deficiency in pregnancy is prevalent in developed countries.

【 授权许可】

Unknown