Extracellular Vesicles Promote the Formation of Pre-Metastasis Niche in Gastric Cancer

Frontiers in Immunology

Gongping Deng¹  Shan Zeng²  Hong Shen³  Diya Tang³  Shanshan Liu³ 

[1] Department of Emergency, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China;Department of Oncology, Xiangya Hospital, Central South University, Changsha, China;National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China;

关键词: gastric cancer;    extracellular vesicles;    immunomodulation;    pre-metastatic;    microenvironment;   

DOI  :  10.3389/fimmu.2022.813015

来源: DOAJ

【 摘 要 】

Globally, gastric cancer (GC) ranks fourth in the incidence of malignant tumors. The early clinical manifestations of GC lack specificity. Most patients are already at an advanced stage when they are first diagnosed, and their late progression is mainly due to peritoneal metastasis. A pre-metastatic microenvironment is formed, before the macroscopic tumor metastasis. Extracellular vesicles (EVs) are nanovesicles released by cells into body fluids. Recent studies have shown that EVs can affect the tumor microenvironment by carrying cargos to participate in cell-to-cell communication. EVs derived from GC cells mediate the regulation of the pre-metastasis niche and act as a coordinator between tumor cells and normal stroma, immune cells, inflammatory cells, and tumor fibroblasts to promote tumor growth and metastasis. This review highlights the regulatory role of EVs in the pre-metastatic niche of GC and mulls EVs as a potential biomarker for liquid biopsy.

【 授权许可】

Unknown