Translational Relevance of Mouse Models of Atopic Dermatitis

Journal of Clinical Medicine

MadanM. Kwatra¹  Zachary Bordeaux²  ShawnG. Kwatra²  Justin Choi²  YoukyungSophie Roh²  MartinP. Alphonse²  Nishadh Sutaria² 

[1] Department of Anesthesiology, Duke University School of Medicine, Durham, NC 27710, USA;Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA;

关键词: atopic dermatitis;    eczema;    mouse models;    dermatology;    immunology;   

DOI  :  10.3390/jcm10040613

来源: DOAJ

【 摘 要 】

The complexity of atopic dermatitis (AD) continues to present a challenge in the appropriate selection of a mouse model because no single murine model completely recapitulates all aspects of human AD. This has been further complicated by recent evidence of the distinct AD endotypes that are dictated by unique patterns of inflammation involving Th1, Th2, Th17, and Th22 axes. A review of currently used mouse models demonstrates that while all AD mouse models consistently exhibit Th2 inflammation, only some demonstrate concomitant Th17 and/or Th22 induction. As the current understanding of the pathogenic contributions of these unique endotypes and their potential therapeutic roles expands, ongoing efforts to maximize a given mouse model’s homology with human AD necessitates a close evaluation of its distinct immunological signature.

【 授权许可】

Unknown