Dysregulation of microRNA and Intracerebral Hemorrhage: Roles in Neuroinflammation

International Journal of Molecular Sciences

Hisham Kashif¹  Dilan Shah¹  Sangeetha Sukumari-Ramesh¹ 

[1] Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA;

关键词: ICH;    microRNA;    miR;    neuroinflammation;   

DOI  :  10.3390/ijms22158115

来源: DOAJ

【 摘 要 】

Intracerebral hemorrhage (ICH) is a major public health problem and devastating subtype of stroke with high morbidity and mortality. Notably, there is no effective treatment for ICH. Neuroinflammation, a pathological hallmark of ICH, contributes to both brain injury and repair and hence, it is regarded as a potential target for therapeutic intervention. Recent studies document that microRNAs, small non-coding RNA molecules, can regulate inflammatory brain response after ICH and are viable molecular targets to alter brain function. Therefore, there is an escalating interest in studying the role of microRNAs in the pathophysiology of ICH. Herein, we provide, for the first time, an overview of the microRNAs that play roles in ICH-induced neuroinflammation and identify the critical knowledge gap in the field, as it would help design future studies.

【 授权许可】

Unknown