Decreased CX3CL1 Levels in the Cerebrospinal Fluid of Patients With Alzheimer’s Disease

Frontiers in Neuroscience

Alberto Lleó²  Juan Fortea²  Daniel Alcolea²  Marta Bolós³  Juan R. Perea³  Jesús Ávila³ 

[1]Department of Molecular Neuropathology, Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Madrid, Spain

[2]Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain

[3]Network Center for Biomedical Research on Neurodegenerative Diseases, Madrid, Spain

关键词: CX3CL1;    Alzheimer’s disease;    tau;    microglia;    human CSF;    inflammation;   

DOI  :  10.3389/fnins.2018.00609

来源: DOAJ

【 摘 要 】

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by the presence of neurofibrillary tangles, constituted by tau protein, and plaques formed by amyloid-beta protein. The disease courses with high neural damage, which leads to memory loss and death. Here we analyzed the presence of CX3CL1, a chemokine expressed by neurons, in cerebrospinal fluid (CSF) samples from control subjects and patients with mild cognitive impairment and AD dementia. CX3CL1 was decreased in the CSF of AD dementia patients compared to control subjects. However, there was not difference in plasma samples from the same subjects.

【 授权许可】

Unknown