The emerging molecular mechanism of m6A modulators in tumorigenesis and cancer progression

Biomedicine & Pharmacotherapy

Xiaotong Hu¹  Qin Zhang²  Bingtao Zhai²  Qiujie Li³  Lvjia Zhuo³  Ke Chen⁴  Xinbing Sui⁵  Tian Xie⁶  Guohua Li⁶  Shuiping Liu⁶ 

[1] Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, China;Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, College of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China;Key Laboratory of Elemene Class Anti-cancer Chinese Medicine of Zhejiang Province, College of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China;Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, China;Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, China;Holistic Integrative Pharmacy Institutes, College of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China;

关键词: M6A modification;    Tumorigenesis;    Cancer progression;    Diagnostic biomarker;    Cancer therapy;   

DOI  :  

来源: DOAJ

【 摘 要 】

N6-methyladenosine (m6A) is the most abundant RNA modification; m6A modifications are installed by methyltransferases, removed by demethylases and recognized by reader proteins. M6A plays crucial roles in a variety of biological processes by regulating target RNA translation, splicing, nuclear export, and decay. Since the establishment of methylated RNA immunoprecipitation-sequencing methodology, over three hundred articles about m6A modulators, including ''writers'', ''erasers'' and ''readers'', have been reported in the last four years. In addition, an increasing number of molecular mechanisms underlying m6A RNA methylation in human cancers have been comprehensively clarified. The recently emerged molecular mechanisms of m6A modulators in cancer cell proliferation, cell cycle progression, migration and invasion, apoptosis, and autophagy remain to be summarized. Hence, this review specifically summarizes these recent advances in the understanding of m6A molecular mechanisms in tumorigenesis and cancer progression. In addition, we discuss the prospect of using an m6A methylation modulator as a new diagnostic biomarker and therapeutic target for human cancers.

【 授权许可】

Unknown