ICP-MS Multi-Elemental Analysis of the Human Meninges Collected from Sudden Death Victims in South-Eastern Poland

Molecules

Jacek Baj¹  Wojciech Flieger¹  Grzegorz Teresiński²  Paweł Kędzierawski²  Tomasz Cywka²  Alicja Forma²  Grzegorz Buszewicz²  Kaja Hanna Karakuła³  Jolanta Flieger⁴  Tomasz Krajka⁵  Beata Kowalska⁶ 

[1]Chair and Department of Anatomy, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland

[2]Chair and Department of Forensic Medicine, Medical University of Lublin, 20-090 Lublin, Poland

[3]Chair and I Department of Psychiatry, Psychotherapy, and Early Intervention, Medical University of Lublin, 20-439 Lublin, Poland

[4]Department of Analytical Chemistry, Medical University of Lublin, Chodźki 4A, 20-093 Lublin, Poland

[5]Department of Production Computerisation and Robotisation, Mechanical Engineering Faculty, Lublin University of Technology, Nadbystrzycka 36, 20-618 Lublin, Poland

[6]Department of Water Supply and Wastewater Disposal, Lublin University of Technology, Nadbystrzycka 40B, 20-618 Lublin, Poland

关键词: multi-elemental analysis;    trace elements;    human brain;    dura mater;    arachnoid mater;    ICP-MS;   

DOI  :  10.3390/molecules27061911

来源: DOAJ

【 摘 要 】

Metals perform many important physiological functions in the human body. The distribution of elements in different tissues is not uniform. Moreover, some structures can be the site of an accumulation of essential or toxic metals, leading to multi-directional intracellular damage. In the nervous system, these disorders are especially dangerous. Metals dyshomeostasis has been linked to a variety of neurological disorders which end up leading to permanent injuries. The multi-elemental composition of the human brain is still the subject of numerous investigations and debates. In this study, for the first time, the meninges, i.e., the dura mater and the arachnoid, were examined for their elemental composition by means of inductively coupled plasma mass spectrometry (ICP-MS). Tissue samples were collected post mortem from those who died suddenly as a result of suicide (n = 20) or as a result of injuries after an accident (n = 20). The interactions between 51 elements in both groups showed mainly weak positive correlations, which dominated the arachnoid mater compared to the dura mater. The study showed differences in the distribution of some elements within the meninges in the studied groups. The significant differences concerned mainly metals from the lanthanide family (Ln), macroelements (Na, K, Ca, Mg), a few micronutrients (Co), and toxic cadmium (Cd). The performed evaluation of the elemental distribution in the human meninges sheds new light on the trace metals metabolism in the central nervous system, although we do not yet fully understand the role of the human meninges.

【 授权许可】

Unknown