Prospective Comparison of F-18 Choline PET/CT Scan Versus Axial MRI for Detecting Bone Metastasis in Biochemically Relapsed Prostate Cancer Patients

Diagnostics

Kathia De Man¹  Valerie Fonteyne²  Piet Ost²  Aurélie De Bruycker²  Gert De Meerleer³  Frédéric Lecouvet⁴  Marie-Laurence Denis⁴  Lennart Jans⁵  Wouter Huysse⁵  Valerie Lambrecht⁵  Karel Decaestecker⁶  Louke Delrue⁷  Carlos Artigas⁸  Filip De Vos⁹  Bieke Lambert⁹  Paolo Castellucci^1,10 

[1] Department of Nuclear Medicine, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium;Department of Radiation Oncology and Experimental Cancer Research, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium;Department of Radiation Oncology and Experimental Cancer Research, UZ Leuven, Herestraat 49, 3000 Leuven, Belgium;Department of Radiology, Centre du Cancer and Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Avenue Hippocrate 10/2942, B-1200 Brussels, Belgium;Department of Radiology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium;Department of Urology and Experimental Cancer Research, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium;Laboratory of Radiopharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium;Nuclear Medicine, Institut Jules Bordet, Waterloolaan 121, 1000 Brussels, Belgium;Radiology and Nuclear Medicine, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium;Service of Nuclear Medicine, Policlinico Sant’Orsola-Malpighi, University of Bologna, 40126 Bologna, Italy;

关键词: choline PET/CT;    MRI;    bone metastasis;    prostate cancer;   

DOI  :  10.3390/diagnostics7040056

来源: DOAJ

【 摘 要 】

We compared fluor-18 choline positron emission tomography/computed tomography (PET/CT) and axial skeleton magnetic resonance imaging (MRI) prospectively obtained for the detection of bone metastases in non-castrated patients with biochemically recurrent prostate cancer following primary treatment. PET/CT was performed 45 min post-injection of 3–4 MBq/kg F-18 methyl choline. MRI included T1- and fluid sensitive T2-weighted images of the spine and pelvis. Readers were initially blinded from other results and all scans underwent independent double reading. The best valuable comparator (BVC) defined the metastatic status. On the basis of the BVC, 15 out of 64 patients presented with 24 bone metastases. On a patient level, the sensitivity and specificity of MRI and PET were not significantly different. On a lesion level, the sensitivity of MRI was significantly better compared to PET, and the specificity did not differ significantly. In conclusion, axial MRI is an interesting screening tool for the detection of bone metastases because of its low probability of false negative results. However, F-18 choline PET is a valuable addition as it can overrule false positive MRI results and detect non-axial metastases.

【 授权许可】

Unknown