Environmental Monitoring of PAHs Exposure, Biomarkers and Vital Status in Coke Oven Workers

International Journal of Environmental Research and Public Health

Domenica Cavone¹  GiovanniMaria Ferri²  Antonio Caputi²  MariaCeleste Delfino²  Luigi Vimercati²  Luigi De Maria²  Vincenzo Corrado²  Lucia Bisceglia³ 

[1] 52 G. Gentile Street, 70126 Bari, Italy;Interdisciplinary Department of Medicine, Occupational Medicine “B. Ramazzini”, University of Bari Medical School, 11 G. Cesare Square, 70124 Bari, Italy;Strategic Regional Health and Social Agency of Puglia (AReS Puglia);

关键词: cohort;    coke plant;    biomarkers;    vital status;    occupational exposure;    sister chromatid exchange;    urinary 1-hydroxypyrene (1-ohpy), pah dna adducts;    total nitro-pah hemoglobin adducts;   

DOI  :  10.3390/ijerph17072199

来源: DOAJ

【 摘 要 】

A follow-up study of a cohort of workers from a coke plant compared with a control group from the same industrial area was conducted in 2019. The recruitment and environmental and biomarker measurements were performed during 1993/1994. The environmental concentrations of polycyclic aromatic hydrocarbons (PAH), B(a)P, pyrene and nitro-PAH were measured. Personal data were collected via an individual semi-structured questionnaire by a trained physician. All biomarkers were measured after a specific blood drawing for every test. Significant risks (ORs) were observed for nitro-PAH (≥0.12 µg/m³) [OR = 7.96 (1.01−62.82)], urinary 1-hydroxypyrene (1-OHpy) (≥0.99 µmoles/moles of creatinine) [OR = 11.71 (1.47−92.90)], PAH DNA adducts (P³²) (≥2.69 adducts/10⁸ nucleotides) [OR = 5.46 (1.17−25.58)], total nitro-PAH hemoglobin adducts (≥161.68 fg/µg of Hb) [OR = 5.92 (1.26−27.86)], sister chromatid exchange (SCE) with TCR (≥377.84 SCE/cell chromosomes) [OR = 13.06 (3.95−93.10)], sister chromatid exchange with T (≥394.72 total SCE) [OR = 13.06 (3.95−93.10)], and sister chromatid exchange with X (≥8.19 mean SCE) [OR = 13.06 (3.95−93.10)]. Significant risk of death for all causes and chromosomal aberrations (48 h) (OR = 7.19 [1.19−43.44]) or micronuclei in culture at 48 h (OR = 3.86 [1.04−14.38]) were also found.

【 授权许可】

Unknown