One-pot activation–alkynylation–cyclization synthesis of 1,5-diacyl-5-hydroxypyrazolines in a consecutive three-component fashion

Beilstein Journal of Organic Chemistry

Guido J. Reiss¹  Walter Frank¹  Christina Görgen²  Thomas J. J. Müller²  Katharina Boden² 

[1] Heinrich-Heine Universität Düsseldorf, Institut für Anorganische Chemie und Makromolekulare Chemie, Universitätsstraße 1, D-40225 Düsseldorf, Germany;Heinrich-Heine Universität Düsseldorf, Institut für Organische Chemie und Makromolekulare Chemie, Universitätsstraße 1, D-40225 Düsseldorf, Germany;

关键词: activation;    alkynylation;    C–C coupling;    copper;    cyclization;    multicomponent reactions;   

DOI  :  10.3762/bjoc.15.136

来源: DOAJ

【 摘 要 】

A consecutive three-component activation–alkynylation–cyclization reaction of (hetero)aryl glyoxylic acids, oxalyl chloride, arylacetylenes, and hydrazides efficiently forms 1,5-diacyl-5-hydroxypyrazolines in moderate to good yields. The structures were unambiguously corroborated by comprehensive NMR spectroscopy and X-ray structure analyses of selected derivatives.

【 授权许可】

Unknown