Validation of the effectiveness of SARS-CoV-2 vaccines in older adults in “real-world” settings

Immunity & Ageing

Graham Pawelec¹  Nan-ping Weng² 

[1] Department of Immunology, University of Tübingen;Laboratory of Molecular Biology and Immunology, National Institute on Aging, NIH;

关键词: SARS-CoV-2;    Vaccination;    COVID-19;    Longevity of vaccine response;    Neutralizing mAb;    Aging;   

DOI  :  10.1186/s12979-021-00248-7

来源: DOAJ

【 摘 要 】

Abstract The rapidity of SARS-CoV-2 vaccination around the world has substantially reduced the number of new cases of COVID-19 and their severity in highly vaccinated countries. The unanticipated efficacy of SARS-CoV-2 vaccines in older adults has been very encouraging but the longevity of vaccine immunity is currently unknown and protection against emerging variants may be lower. Adoptive immunotherapy with neutralizing mAb may offer an alternative for poor vaccine responders, while the mechanisms underlying failure to respond are still unclear. Further studies of B and T cell responses and their regulation particularly in older populations will provide a more solid foundation to develop suitable approaches to optimize vaccine responses of older adults who fail to mount a durable response.

【 授权许可】

Unknown