The function and regulation network mechanism of circRNA in liver diseases

Cancer Cell International

Limin Liu¹  Zengli Yu¹  Panpan Wang¹  Peisen Guo¹  Nan Liu¹  Zhi Qu²  Yunhuan Zhang²  Peixi Wang²  Lugang Deng³ 

[1] College of Public Health, Zhengzhou University;Institute of Chronic Disease Risks Assessment, School of Nursing and Health, Henan University;South China Hospital, Health Science Center, Shenzhen University;

关键词: circRNA;    Liver diseases;    Hepatocellular carcinoma (HCC);    Biomarker;    miRNA sponge;   

DOI  :  10.1186/s12935-022-02559-1

来源: DOAJ

【 摘 要 】

Abstract Circular RNA (circRNA), a new type of endogenous non-coding RNA, is abundantly present in eukaryotic cells, and characterized as stable high conservation and tissue specific expression. It has been generated increasing attention because of their close association with the progress of diseases. The liver is the vital organ of humans, while it is prone to acute and chronic diseases due to the influence of multiple pathogenic factors. Moreover, hepatocellular carcinoma (HCC) is the one of most common cancer and the leading cause of cancer death worldwide. Overwhelming evidences indicate that some circRNAs are differentially expressed in liver diseases, such as, HCC, chronic hepatitis B, hepatic steatosis and hepatoblastoma tissues, etc. Additionally, these circRNAs are related to proliferation, invasion, migration, angiogenesis, apoptosis, and metastasis of cell in liver diseases and act as oncogenic agents or suppressors, and linked to clinical manifestations. In this review, we briefly summarize the biogenesis, characterization and biological functions, recent detection and identification technologies of circRNA, and regulation network mechanism of circRNA in liver diseases, and discuss their potential values as biomarkers or therapeutic targets for liver diseases, especially on HCC.

【 授权许可】

Unknown