An Overview of the Molecular Mechanisms Associated with Myocardial Ischemic Injury: State of the Art and Translational Perspectives

Cells

Valentina Valenti¹  Giulia Spinosa¹  Gianmarco Sarto¹  Vincenzo Petrozza¹  Leonardo Schirone¹  Giacomo Frati¹  Daniele Vecchio¹  Sonia Schiavon¹  Luca D’Ambrosio¹  Maurizio Forte²  Sebastiano Sciarretta² 

[1] Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy;IRCCS Neuromed, 86077 Pozzilli, Italy;

关键词: ischemic injury;    myocardial ischemia;    infarction;    ischemia/reperfusion (I/R);    molecular;    mechanisms;   

DOI  :  10.3390/cells11071165

来源: DOAJ

【 摘 要 】

Cardiovascular disease is the leading cause of death in western countries. Among cardiovascular diseases, myocardial infarction represents a life-threatening condition predisposing to the development of heart failure. In recent decades, much effort has been invested in studying the molecular mechanisms underlying the development and progression of ischemia/reperfusion (I/R) injury and post-ischemic cardiac remodeling. These mechanisms include metabolic alterations, ROS overproduction, inflammation, autophagy deregulation and mitochondrial dysfunction. This review article discusses the most recent evidence regarding the molecular basis of myocardial ischemic injury and the new potential therapeutic interventions for boosting cardioprotection and attenuating cardiac remodeling.

【 授权许可】

Unknown