Interrogating Epigenome toward Personalized Approach in Cutaneous Melanoma

Journal of Personalized Medicine

Elena-Georgiana Dobre¹  Marieta Costache¹  Monica Neagu¹  Carolina Constantin² 

[1] Faculty of Biology, University of Bucharest, Splaiul Independentei 91–95, 050095 Bucharest, Romania;Immunology Department, “Victor Babes” National Institute of Pathology, 050096 Bucharest, Romania;

关键词: cutaneous melanoma;    epigenetic regulation;    inflammation;    drug resistance;    biomarkers;    therapeutic targets;   

DOI  :  10.3390/jpm11090901

来源: DOAJ

【 摘 要 】

Epigenetic alterations have emerged as essential contributors in the pathogenesis of various human diseases, including cutaneous melanoma (CM). Unlike genetic changes, epigenetic modifications are highly dynamic and reversible and thus easy to regulate. Here, we present a comprehensive review of the latest research findings on the role of genetic and epigenetic alterations in CM initiation and development. We believe that a better understanding of how aberrant DNA methylation and histone modifications, along with other molecular processes, affect the genesis and clinical behavior of CM can provide the clinical management of this disease a wide range of diagnostic and prognostic biomarkers, as well as potential therapeutic targets that can be used to prevent or abrogate drug resistance. We will also approach the modalities by which these epigenetic alterations can be used to customize the therapeutic algorithms in CM, the current status of epi-therapies, and the preliminary results of epigenetic and traditional combinatorial pharmacological approaches in this fatal disease.

【 授权许可】

Unknown