Predictive Factors for Hepatocellular Carcinoma Development after Direct-Acting Antiviral Treatment of HCV

Livers

Komal Saleem¹  Samia Afzal¹  Zuzana Macek Jilkova²  Thomas Decaens² 

[1] Centre of Excellence in Molecular Biology, University of The Punjab, Lahore 54000, Pakistan;Université Grenoble Alpes, 38000 Grenoble, France;

关键词: HCV;    HCC;    DAA;    liver;    predictive factors;   

DOI  :  10.3390/livers1040024

来源: DOAJ

【 摘 要 】

Chronic hepatitis C virus infection is still one of the major risk factors for the development of hepatocellular carcinoma (HCC), the most frequent type of primary liver cancer. Direct-acting antivirals have substantially improved the cure rate of the virus, but the risk of hepatitis C virus-related HCC remains high, mainly in patients with advanced liver fibrosis and cirrhosis. HCC is often asymptomatic and, therefore, remains undetected until the late tumor stage, which is associated with poor survival rates. Therefore, to improve the surveillance programs following HCV eradication, there is a need to summarize predictive factors or potential biomarkers, to specifically identify patients likely to develop HCC after direct-acting antiviral treatment. This review outlines the most recent data about different predictive factors for HCC development after direct-acting antiviral treatment of hepatitis C virus-infected patients, to improve the clinical management of patients with chronic hepatitis C virus.

【 授权许可】

Unknown