One‐Pot Synthesis of Customized Metal–Phenolic‐Network‐Coated AIE Dots for In Vivo Bioimaging

Advanced Science

Xueqin Yang¹  Jun Zhang¹  Jacky W. Y. Lam¹  Xuewen He¹  Ruoyao Zhang¹  Chen Peng¹  Ryan T. K. Kwok¹  Junyi Gong¹  Bo Yan²  Changhuo Xu³  Ben Zhong Tang³  Zheng Zhao³ 

[1] Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction The Hong Kong University of Science and Technology Hong Kong 999077 China;Department of Radiology Shanghai Public Health Clinical Center Fudan University Shanghai 201508 China;Shenzhen Institute of Aggregate Science and Technology School of Science and Engineering The Chinese University of Hong Kong Shenzhen 518172 China;

关键词: aggregation‐induced emission;    coacervation;    fluorescence imaging;    magnetic resonance imaging;    metal–phenolic networks;   

DOI  :  10.1002/advs.202104997

来源: DOAJ

【 摘 要 】

Abstract The integration of aggregation‐induced emission luminogens (AIEgens) and inorganic constituents to generate multifunctional nanocomposites has attracted much attention because it couples the bright aggregate‐state fluorescence of AIEgens with the diverse imaging modalities of inorganic constituents. Herein, a facile and universal strategy to prepare metal–phenolic‐network (MPN)‐coated AIE dots in a high encapsulation efficiency is reported. Through precise control on the nucleation of AIEgens and deposition of MPNs in tetrahydrofuran/water mixtures, termed as coacervation, core–shell MPN‐coated AIE dots with bright emission are assembled in a one‐pot fashion. The optical properties of MPN‐coated AIE dots can be readily tuned by varying the incorporated AIEgens. Different metal ions, such as Fe3+, Ti4+, Cu2+, Ni2+, can be introduced to the nanoparticles. The MPN‐coated AIE dots with a red‐emissive AIEgen core are successfully used to perform magnetic resonance/fluorescence dual‐modality imaging in a tumor‐bearing mouse model and blood flow visualization in a zebrafish larva. It is believed that the present study provides a tailor‐made nanoplatform to meet the individual needs of in vivo bioimaging.

【 授权许可】

Unknown