ACE2 in the Gut: The Center of the 2019-nCoV Infected Pathology

Frontiers in Molecular Biosciences

Lei Gao¹  Rongxuan Hua²  Yuexin Guo³  Jing-Dong Xu⁴  Han Gao⁴  Boya Wang⁵ 

[1] Department of Bioinformatics, School of Biomedical Engineering, Capital Medical University, Beijing, China;Department of Clinical Medicine "5+3" Program, Basic Medical College, Capital Medical University, Beijing, China;Department of Oral Medicine "5+3" Program, Basic Medical College, Capital Medical University, Beijing, China;Department of Physiology and Pathophysiology, Basic Medical College, Capital Medical University, Beijing, China;Undergraduate Student of 2018 Eight Program of Clinical Medicine, Peking University Health Science Center, Beijing, China;

关键词: ACE2;    2019-nCoV;    gut;    function;    biological actions;   

DOI  :  10.3389/fmolb.2021.708336

来源: DOAJ

【 摘 要 】

The 2019-nCoV is a rapidly contagious pneumonia caused by the recently discovered coronavirus. Although generally the most noticeable symptoms are concentrated in the lungs, the disorders in the gastrointestinal tract are of great importance in the diagnosis of 2019-nCoV. The angiotensin-converting enzyme 2 (ACE2), an important regulator of many physiological functions, including blood pressure and nutrients absorption, is recently identified as a vital entry for 2019-nCoV to enter host cells. In this review, we summarize its functions both physiologically and pathologically. We also elaborate its conflicting roles from the clews of contemporary researches, which may provide significant indications for pharmacological investigations and clinical uses.

【 授权许可】

Unknown