CYP2D6 1846 G/A gene polymorphism in association with Hemorrhagic Stroke/Aneurysm in patients from the Federal District (Brazil)

REVISA

关键词: acidente vascular cerebral;    polimorfismo genético;    citocromo p-450 cyp2d6;    hipertensão;    diabetes mellitus.;   

DOI  :  10.3623/revisa.v%.n%.p461%

来源: DOAJ

【 摘 要 】

Objective: To investigate a possible association of the CYP2D6 1846 G/A gene in HS/aneurysm patients residing in the Federal District (Brazil), as well as to crosscheck the information obtained with clinical manifestations and prognosis. Method: The investigation was a population-based case-control study involving 81 cases with HS/aneurysm. The samples genotyping employed the PCR-RFLP technique with a significance level of 5%. Results: The attempt to associate genotypic and allelic frequencies to the HVA/Aneurysm resulted in no statistical difference. Nevertheless, in patients with the GG genotype and hypertension, the risk for HS increased 44 times. Participants with GG genotype also had statistically higher glycemia mean levels in the case group. Conclusion: The presence of the CYP2D6 1846 G/A polymorphism should be extensively, as it is necessary to clarify whether such polymorphisms represent associations with HS and Intracerebral Aneurysm.

【 授权许可】

Unknown