Functional activity and peripheral insulin resistance in patients with different types of onset of diabetes mellitus

Сахарный диабет

Ivan Ivanovich Dedov¹  Elena Vladimirovna Pekareva¹  Tatiana Vasil'evna Nikonova¹ 

[1] Endocrinology Research Centre, Moscow;

关键词: lada;    homa;    diabetes mellitus;    lada;    insulin resistance;    homa;   

DOI  :  10.14341/2072-0351-6082

来源: DOAJ

【 摘 要 】

Aim.To evaluate changes in functional activity and insulin resistance (IR) in patients with different types of onset of diabetes mellitus(DM). Materials and methods.We examined 166 subjects which were subdivided into 4 study groups and 1 control group. Assessment of totalbeta-cell functional activity and degree of IR (according to HOMA-model) was conducted in patients with different variants of DM onsetand in the group of high risk for type 1 DM. Results.The most significant decrease in beta-cell functional activity was found in patients with type 1 diabetes mellitus (HOMA-F 8.9%).Onset of LADA (Latent autoimmune diabetes in adults) and type 2 diabetes mellitus (T2DM) was also characterized by decreasein beta-cell functional activity (HOMA-F 39.2% and 63.9%, respectively), as well as by development of IR: HOMA-IR 3.7 and 7.2,respectively. Conclusion.Clinical onset of LADA and T2DM occurs against the background of decreased beta-cell functional activity and compromisedperipheral insulin sensitivity.

【 授权许可】

Unknown