Neutrophils in traumatic brain injury (TBI): friend or foe?

Journal of Neuroinflammation

Song Li¹  Yang-Wuyue Liu²  Shuang-Shuang Dai² 

[1] Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh;Department of Biochemistry and Molecular Biology, Army Medical University;

关键词: Neutrophils;    Polymorphonuclear cell;    Traumatic brain injury;    Edema;    Neuroinflammation;    Blood-brain barrier;   

DOI  :  10.1186/s12974-018-1173-x

来源: DOAJ

【 摘 要 】

Abstract Our knowledge of the pathophysiology about traumatic brain injury (TBI) is still limited. Neutrophils, as the most abundant leukocytes in circulation and the first-line transmigrated immune cells at the sites of injury, are highly involved in the initiation, development, and recovery of TBI. Nonetheless, our understanding about neutrophils in TBI is obsolete, and mounting evidences from recent studies have challenged the conventional views. This review summarizes what is known about the relationships between neutrophils and pathophysiology of TBI. In addition, discussions are made on the complex roles as well as the controversial views of neutrophils in TBI.

【 授权许可】

Unknown