International Journal of Molecular Sciences | |
Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment | |
DavidJ. Tweardy1  MosesM. Kasembeli1  Uddalak Bharadwaj1  Prema Robinson1  | |
[1] Department of Infectious Disease, Infection Control and Employee Health, Division of Internal Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; | |
关键词: STAT3; asthma; inflammatory bowel disease (IBD); ulcerative colitis (UC); Crohn’s disease (CD); fibrosis; cachexia; | |
DOI : 10.3390/ijms19082299 | |
来源: DOAJ |
【 摘 要 】
Signal transducer and activator of transcription (STAT) 3 plays a central role in the host response to injury. It is activated rapidly within cells by many cytokines, most notably those in the IL-6 family, leading to pro-proliferative and pro-survival programs that assist the host in regaining homeostasis. With persistent activation, however, chronic inflammation and fibrosis ensue, leading to a number of debilitating diseases. This review summarizes advances in our understanding of the role of STAT3 and its targeting in diseases marked by chronic inflammation and/or fibrosis with a focus on those with the largest unmet medical need.
【 授权许可】
Unknown