Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment

International Journal of Molecular Sciences

DavidJ. Tweardy¹  MosesM. Kasembeli¹  Uddalak Bharadwaj¹  Prema Robinson¹ 

[1] Department of Infectious Disease, Infection Control and Employee Health, Division of Internal Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;

关键词: STAT3;    asthma;    inflammatory bowel disease (IBD);    ulcerative colitis (UC);    Crohn’s disease (CD);    fibrosis;    cachexia;   

DOI  :  10.3390/ijms19082299

来源: DOAJ

【 摘 要 】

Signal transducer and activator of transcription (STAT) 3 plays a central role in the host response to injury. It is activated rapidly within cells by many cytokines, most notably those in the IL-6 family, leading to pro-proliferative and pro-survival programs that assist the host in regaining homeostasis. With persistent activation, however, chronic inflammation and fibrosis ensue, leading to a number of debilitating diseases. This review summarizes advances in our understanding of the role of STAT3 and its targeting in diseases marked by chronic inflammation and/or fibrosis with a focus on those with the largest unmet medical need.

【 授权许可】

Unknown