Cross With Caution: Antibiotic Cross-Reactivity and Co-Reactivity Patterns in Severe Cutaneous Adverse Reactions

Frontiers in Immunology

Michaela Lucas¹  Grace Thompson²  Andrew McLean-Tooke² 

[1] Medical School, University of Western Australia, Nedlands, WA, Australia;Queen Elizabeth II Medical Centre, Department of Clinical Immunology, Sir Charles Gairdner Hospital, Pathwest, Nedlands, WA, Australia;

关键词: severe cutaneous adverse drug reactions;    antibiotic cross-reactivity;    antibiotic co-reactivity;    beta-lactam;    antibiotics;   

DOI  :  10.3389/fimmu.2021.601954

来源: DOAJ

【 摘 要 】

Current understanding of cross-reactivity in severe cutaneous adverse reactions to beta-lactam antibiotics is limited, thereby making recommendations for future prescribing difficult. The underlying immunopathogenesis of these reactions is not completely understood but involves interactions between small molecule drugs, T cells and HLA molecules. Historically, these reactions were considered to be specific to the inciting antibiotic and therefore likely to have minimal cross-reactivity. We assessed patients presenting with non-SJS/TEN severe cutaneous adverse reactions to a tertiary hospital drug allergy clinic. In our case series cross-reactivity or co-reactivity commonly occurred among the beta-lactam antibiotic class, however further research is required to investigate and understand patterns of cross-reactivity. Based on our experience we provide clinicians with a practical algorithm for testing for cross-reactivity in non-SJS/TEN severe cutaneous adverse reactions.

【 授权许可】

Unknown