Defects of Nutrient Signaling and Autophagy in Neurodegeneration

Frontiers in Cell and Developmental Biology

Laura Rodriguez-Gómez¹  Andrés Jiménez-Zúñiga¹  Francisco Javier Gil-Bea¹  Haizea Hernandez-Eguiazu¹  Jon Ondaro¹  Maddi Garciandia-Arcelus¹  Julen Goikolea³  Patricia Rodriguez-Rodriguez³  Raúl Loera-Valencia³  Gorka Gereñu⁵  Adolfo Lopez de Munain⁶  Javier Ruiz-Martinez⁶  Fermín Moreno⁶  Ian James Holt⁷ 

[1] Center for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Madrid, Spain;Department of Clinical and Movement Neurosciences, Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom;Department of Neurology, Care Sciences and Society, Center for Alzheimer Research, Karolinska Institutet (KI), Stockholm, Sweden;Department of Neuroscience, Biodonostia Health Research Institute (IIS Biodonostia), San Sebastian, Spain;Department of Physiology, Faculty of Medicine and Nursing, University of Basque Country (UPV-EHU), Leioa, Spain;Donostia University Hospital, San Sebastian, Spain;IKERBASQUE Basque Foundation for Science, Bilbao, Spain;

关键词: neurodegenerative diseases;    autophagy;    nutrient sensing pathways;    mitochondrial metabolism;    lipid metabolism;    glucose metabolism;   

DOI  :  10.3389/fcell.2022.836196

来源: DOAJ

【 摘 要 】

Neurons are post-mitotic cells that allocate huge amounts of energy to the synthesis of new organelles and molecules, neurotransmission and to the maintenance of redox homeostasis. In neurons, autophagy is not only crucial to ensure organelle renewal but it is also essential to balance nutritional needs through the mobilization of internal energy stores. A delicate crosstalk between the pathways that sense nutritional status of the cell and the autophagic processes to recycle organelles and macronutrients is fundamental to guarantee the proper functioning of the neuron in times of energy scarcity. This review provides a detailed overview of the pathways and processes involved in the balance of cellular energy mediated by autophagy, which when defective, precipitate the neurodegenerative cascade of Parkinson’s disease, frontotemporal dementia, amyotrophic lateral sclerosis or Alzheimer’s disease.

【 授权许可】

Unknown