Association Between Psoriasis and Dementia: Current Evidence

Frontiers in Aging Neuroscience

Yan Qiang¹  Hong-jin Li³  Ya-qiong Zhou³  Bin Li³  Xiao-ying Sun³  Xin Li³  Le Kuai⁴  Yi Ru⁴  Si-ting Chen⁴  Liu Liu⁴  Ying Luo⁴  Meng Xing⁴  Xiao-jie Ding⁴ 

[1] Department of Dermatology, Songjiang Hospital Affiliated to Shanghai Jiao Tong University, Jiao Tong University School of Medicine, Shanghai, China;Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China;Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China;Shanghai University of Traditional Chinese Medicine, Shanghai, China;

关键词: psoriasis;    dementia;    systematic review;    meta-analysis;    psoriatic arthritis;   

DOI  :  10.3389/fnagi.2020.570992

来源: DOAJ

【 摘 要 】

Background: Psoriasis and dementia are both inflammatory diseases. The association between psoriasis and dementia has rarely been investigated, and the existing results are conflicting. Thus, we conducted this study to evaluate whether an association exists between psoriasis and dementia.Methods: We searched for studies from six databases from inception to July 30, 2020, using subject and free words. RevMan 5.4 was used to calculate the risk ratio (RR) of dementia in the subjects with psoriasis. When heterogeneity was present, a random-effects model was used. Subgroup, sensitivity, and meta-regression analyses were performed using Stata 15.1.Results: Nine studies were identified and included in the study, of which seven that involved a total of 3,638,487 participants were included in the meta-analysis. We found that among the patients with psoriasis (RR: 1.14, 95% confidence interval [CI]: 1.06–1.24, p = 0.0009) and psoriatic arthritis (RR: 2.20, 95% CI: 1.29–3.78, p = 0.004), the proportions of those with non-vascular dementia (RR: 1.13, 95% CI: 1.11–1.15, p < 0.00001) and vascular dementia (RR: 1.41, 95% CI: 1.09–1.82, p = 0.009) were higher than that among the patients without psoriasis. Those with dementia were also more likely to develop psoriasis, and those with severe psoriasis were less likely to die from dementia (RR: 1.88, 95% CI: 0.72–4.90, p = 0.020). The meta-regression analysis did not show any significant sources of heterogeneity.Conclusions: The patients with psoriasis and psoriatic arthritis show high prevalence of different types of dementia. Based on the findings of this study, dementia may not be considered a high-risk factor of death from severe psoriasis. However, identification of this potential risk allows for early intervention, thereby reducing comorbidities and deaths.

【 授权许可】

Unknown