Neuroendocrine and Metabolic Effects of Low-Calorie and Non-Calorie Sweeteners

Frontiers in Endocrinology

Massimiliano Caprio¹  Mauro Lombardo¹  Vincenzo Marzolla²  Alessandra Feraco²  Eleonora Moriconi³  Marco Infante⁴  Andrea Fabbri⁴ 

[1] Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Rome, Italy;Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, Rome, Italy;Section of Medical Pathophysiology, Food Science and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy;Unit of Endocrinology and Metabolic Diseases, Department of Systems Medicine, CTO A. Alesini Hospital, University of Rome Tor Vergata, Rome, Italy;

关键词: body weight;    microbiota;    safety;    obesity;    diabetes;    sugar;   

DOI  :  10.3389/fendo.2020.00444

来源: DOAJ

【 摘 要 】

Since excessive sugar consumption has been related to the development of chronic metabolic diseases prevalent in the western world, the use of sweeteners has gradually increased worldwide over the last few years. Although low- and non-calorie sweeteners may represent a valuable tool to reduce calorie intake and prevent weight gain, studies investigating the safety and efficacy of these compounds in the short- and long-term period are scarce and controversial. Therefore, future studies will need to elucidate the potential beneficial and/or detrimental effects of different types of sweeteners on metabolic health (energy balance, appetite, body weight, cardiometabolic risk factors) in healthy subjects and patients with diabetes, obesity and metabolic syndrome. In this regard, the impact of different sweeteners on central nervous system, gut hormones and gut microbiota is important, given the strong implications that changes in such systems may have for human health. The aim of this narrative review is to summarize the current evidence for the neuroendocrine and metabolic effects of sweeteners, as well as their impact on gut microbiota. Finally, we briefly discuss the advantages of the use of sweeteners in the context of very-low calorie ketogenic diets.

【 授权许可】

Unknown