High-throughput screening of 756 chemical contaminants in aquaculture products using liquid chromatography/quadrupole time-of-flight mass spectrometry

Food Chemistry: X

Gangjun Chen¹  Suqin Zhu¹  Mingkai Bai²  Wenhai She³  Hongmei Shen³  Hongwei Zhang⁴  Ruixue Tang⁴  Guorong Li⁵  Haohao Wu⁵ 

[1] Institute of Nutrition and Health, School of Public Health, Qingdao University, 308 Ningxia Road, Qingdao 266021, China;College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, Qingdao 266003, China;Guangdong Aquatic Resources Industrialization Engineering Technology Research Center, Guangzhou Luxe Seafood Enterprises Ltd., 1 Lushi Road, Guangzhou 510820, China;Linxia Food Inspection and Testing Center, 8 Renmin Road, Linxia 731100, China;Yin-chuan Administration for Market Regulation, 205 South Limin Street, Yinchuan 750001, China;

关键词: Pesticides;    Veterinary drugs;    POPs;    Marine toxins;    Fish;    Shellfish;   

DOI  :  

来源: DOAJ

【 摘 要 】

A high-throughput screening method embracing 756 multiclass chemical contaminants in aquaculture products was developed using modified QuEChERS extraction coupled with liquid chromatography/quadrupole time-of-flight mass spectrometry. A mega-database with retention time/accurate mass data for 524 pesticides, 182 veterinary drugs, 32 persistent organic pollutants and 18 marine toxins was established for compound identification via retrospective library searching. In the four representative matrices (muscle tissues of tilapia and grouper, and edible portions of oyster and scallop), all the database compounds showed acceptable recovery and repeatability with the screening detection limit and limit of quantification below 0.01 mg/kg for >90% of them. The matrix-matched calibration revealed acceptable quantitative property of the method in terms of linear range, linearity, and matrix effect, and fish muscle samples showed stronger matrix effect than shellfish samples. Analysis of 64 real-life samples from aquaculture farms and retail markets evidenced applicability of the proposed method to high-throughput screening scenarios.

【 授权许可】

Unknown