Associations of clinical outcomes and MRI findings in intra-articular administration of autologous adipose-derived stem cells for knee osteoarthritis

Regenerative Therapy

Tomohiro Terao¹  Sakae Tanaka¹  Yuji Maenohara²  Keita Inoue²  Shinsaku Tsuji²  Taku Saito³  Yasunori Omata³  Ryota Chijimatsu⁴  Junya Higuchi⁵  Fumiko Yano⁵  Ryota Yamagami⁵  Takumi Matsumoto⁵  Tokio Matsuzaki⁵ 

[1] Bone and Cartilage Regenerative Medicine, The University of Tokyo Hospital, Tokyo, Japan;Avenue Cell Clinic, Tokyo, Japan;Bone and Cartilage Regenerative Medicine, The University of Tokyo Hospital, Tokyo, Japan;Japan Biodesign Program, Department of Cardiac Surgery, The University of Tokyo, Tokyo, Japan;Orthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;

关键词: Osteoarthritis;    Adipose-derived stem cell;    Intra-articular administration;    VAS;    KOOS;    MOAKS;   

DOI  :  

来源: DOAJ

【 摘 要 】

Introduction: Clinical studies of intra-articular injection of mesenchymal stem cells for osteoarthritis (OA) indicate its efficacy. Here, we retrospectively investigated the associations of pretherapeutic magnetic resonance imaging (MRI) findings with the clinical outcomes up to 6 months, after intra-articular administration of adipose-derived stem cells (ASCs) to knee OA patients. Methods: We first analyzed alterations of the visual analog scale (VAS) and knee injury and osteoarthritis outcome score (KOOS) in 57 knees of 34 patients from whom clinical scores were obtained before ASC therapy, and at 1, 3, and 6 months. Among the patients, we further examined MRI findings of 34 knees of 19 patients whose pretherapeutic MRI data were available. Results: The mean improvement of VAS and KOOS-total during 6 months was 2.6 ± 4.0 (from 6.1 ± 2.5 to 3.5 ± 2.9, P < 0.001) and 10.2 ± 12.4 (from 54.4 ± 12.7 to 64.6 ± 13.8, P < 0.01), respectively. Scales related to pain and symptoms improved earlier than those related to activities of daily living (ADL) and sports/recreation. Improvement of VAS and KOOS-sports/recreation was significantly higher in patients with more severe cartilage lesions. Similarly, osteophyte lesions were associated significantly with improvement of VAS and KOOS-ADL, and BML was associated with KOOS-ADL and KOOS-sports/recreation. Conclusions: In intra-articular administration of autologous ASCs for knee OA, improvement of VAS and KOOS-sports/recreation was significantly higher in patients with more severe cartilage lesions. Similarly, osteophyte lesions were associated significantly with improvement of VAS and KOOS-ADL, and BML was associated with KOOS-ADL and KOOS-sports/recreation. Clinical studies with larger numbers of patients and various kinds of data are necessary to predict therapeutic effects.

【 授权许可】

Unknown