Genome-wide association meta-analysis identifies 29 new acne susceptibility loci

Nature Communications

Fiona A. Hagenbeek¹  Dorret I. Boomsma¹  Jouke Jan Hottenga¹  Meike Bartels¹  Laurent Thomas²  Jiali Han³  Xin Li³  Nicholas G. Martin⁴  Miguel E. Rentería⁴  Brittany L. Mitchell⁴  Michelle K. Lupton⁴  Michael A. Simpson⁵  Jake R. Saklatvala⁵  Nick Dand⁵  Xianjun Dong⁶  Mari Løset⁷  Kristian Hveem⁷  Josine L. Min⁸  Catherine H. Smith⁹  Jonathan N. Barker⁹ 

[1] Department of Biological Psychology, Vrije Universiteit Amsterdam;Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology;Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health;Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute;Department of Medical and Molecular Genetics, King’s College London;Genomics and Bioinformatics Hub, Brigham and Women’s Hospital;K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology;MRC Integrative Epidemiology Unit, University of Bristol;St John’s Institute of Dermatology, Faculty of Life Sciences & Medicine, King’s College London;

DOI  :  10.1038/s41467-022-28252-5

来源: DOAJ

【 摘 要 】

Better understanding of the genetic basis of acne can pave the way to more effective treatments. Here, the authors perform a genome-wide association study meta-analysis of >20,000 cases and identify 29 new acne susceptibility loci, uncovering genetic links to Mendelian hair and skin disorders and other complex traits.

【 授权许可】

Unknown