International Journal of Molecular Sciences | |
Polycomb Repressor Complex 2 in Genomic Instability and Cancer | |
Kalliopi K. Gkouskou1  Zoe Veneti2  Aristides G. Eliopoulos2  | |
[1] Embiodiagnostics Ltd., 71202 Heraklion, Greece;Molecular and Cellular Biology Laboratory, Division of Basic Sciences, University of Crete Medical School, 71003 Heraklion, Greece; | |
关键词: polycomb; polycomb repressor complex 2; enhancer of zeste homolog 2; DNA damage response; diet; inhibitors; | |
DOI : 10.3390/ijms18081657 | |
来源: DOAJ |
【 摘 要 】
Polycomb repressor complexes PRC1 and PRC2 regulate chromatin compaction and gene expression, and are widely recognized for their fundamental contributions to developmental processes. Herein, we summarize the existing evidence and molecular mechanisms linking PRC-mediated epigenetic aberrations to genomic instability and malignancy, with a particular focus on the role of deregulated PRC2 in tumor suppressor gene expression, the DNA damage response, and the fidelity of DNA replication. We also discuss some of the recent advances in the development of pharmacological and dietary interventions affecting PRC2, which point to promising applications for the prevention and management of human malignancies.
【 授权许可】
Unknown