Virus–Host Interactions Involved in Lassa Virus Entry and Genome Replication

Pathogens

Alejandra D’Antuono¹  Nora López¹  MaríaEugenia Loureiro¹ 

[1] Centro de Virología Animal (CEVAN), CONICET-SENASA, Av Sir Alexander Fleming 1653, Martínez, Provincia de Buenos Aires B1640CSI, Argentina;

关键词: Lassa fever;    arenavirus;    LASV;    virus–host interactions;    entry;    replication;   

DOI  :  10.3390/pathogens8010017

来源: DOAJ

【 摘 要 】

Lassa virus (LASV) is the causative agent of Lassa fever, a human hemorrhagic disease associated with high mortality and morbidity rates, particularly prevalent in West Africa. Over the past few years, a significant amount of novel information has been provided on cellular factors that are determinant elements playing a role in arenavirus multiplication. In this review, we focus on host proteins that intersect with the initial steps of the LASV replication cycle: virus entry and genome replication. A better understanding of relevant virus⁻host interactions essential for sustaining these critical steps may help to identify possible targets for the rational design of novel therapeutic approaches against LASV and other arenaviruses that cause severe human disease.

【 授权许可】

Unknown